Gabapentin as background therapy was administered in open-label conditions to all patients. Subjects were randomized (1:1:1 ratio) to TRZ30 (10 mg three times daily for 8 weeks) or TRZ60 (20 mg three times daily for 8 weeks) or placebo. Male and female diabetic patients aged 18–75 years and affected by painful diabetic neuropathy were eligible for enrollment. This was a randomized, double-blind, placebo-controlled, multi-center, international, prospective study. This phase II study was designed to collect data on the efficacy and safety of low doses of TRZ combined with gabapentin after 8 weeks of treatment in patients affected by painful diabetic neuropathy. Previous clinical trials suggest a possible beneficial effect of low doses of trazodone for the treatment of patients affected by painful diabetic neuropathy. Trazodone (TRZ) is a compound with a multi-modal mechanism of action, being a serotonin-2 antagonist/reuptake inhibitor developed and approved for the treatment of depression in several countries. Monotherapy with available treatments is often not sufficient and a combination of drugs is necessary. It's best to work with a good psychiatrist or a doctor who knows what she or he is doing.Painful diabetic neuropathy is an important therapeutic challenge as the efficacy of analgesic drugs in this setting is still unsatisfactory. It will take a little time to work out how much you should take to work for you. You can't just try a single dose of it one night and expect it to work.

I usually wake up a little groggy but that goes away within 10-15 minutes. I take it at the same time each night just before bed, it puts me to sleep and I STAY ASLEEP for the night. Over a couple of months we figured out the best dosage for me. I finally consulted a psychiatrist who suggested trazodone, in part because it's been around for a while (on the market nearly 4 decades) and its effects are well documented. I had also had a doctor who didn't know what he was doing prescribing me various antidepressants for insomnia. Before that I was on klonopin, benadryl, tylenol pm, ambien, etc, none of which worked well. I’m reconnecting with friends and family as well.Īgain this medication has given me my life back but in a more pleasant mood doing so.ĭownside: my eyes are a little blurry for about a half hour or so upon waking but I’ll take that over the nonexistent life I was living.'įor Insomnia 'I've been on 135 milligrams of trazodone nightly for insomnia for several years and it was absolutely lifesaving. I now get small and big tasks done every day. (I’ve been dealing with these for years now.)ĥ. My major depression, negative thinking, social anxiety are gone. I now have energy that lasts me until bed time.Ĥ. I wake up happy, relaxed and looking forward to the new day. I’d be consumed with thoughts and worry.)Ģ. If I do wake up to go to the bathroom, I’m back to sleep right away.( Before I’d wake up every few hours IF I did fall asleep. This medication has given me my life back.ġ. I take 75-100mg at night 30 mins before bed.

For Insomnia 'My doctor gave Trazodone to me for insomnia.

Max safe dose of trazodone for insomnia